Iron(III) Triflate‐Assisted Skeletal Rearrangement of Warfarin Framework: A Direct Synthetic Route to a Diverse Series of Biorelevant Flavone‐Coumarin Molecular Hybrids

Abstract We herein disclose a new synthetic strategy for a diverse series of biologically interesting flavone‐coumarin molecular hybrids based on iron(III) triflate‐assisted direct and straightforward skeletal rearrangement of warfarin framework upon heating warfarin analogs in N , N‐ dimethylformamide (DMF). Good yields, reasonable reaction time, broad substrate scope and tolerance of various functional groups, scalability, and operational simplicity are the key features of this newly developed method.