Association of proteinuria with improved prognosis in unresectable hepatocellular carcinoma treated with atezolizumab and bevacizumab, and the predictive role of serum vascular endothelial growth factor D levels: A multicenter retrospective study
Grade ≥2 proteinuria in patients with unresectable HCC treated with atezolizumab/bevacizumab indicates a better prognosis, and baseline serum VEGF-D levels can help predict its occurrence. These findings can help in managing adverse events and prognosis in advanced HCC treated with atezolizumab/bevacizumab.
Authors
- Shunichi Hosoda
- Naoki Kawagishi (ORCID: https://orcid.org/0000-0002-2953-6242)
- Shunsuke Ohnishi (ORCID: https://orcid.org/0000-0003-1194-4149)
- Zijian Yang (ORCID: https://orcid.org/0000-0002-3699-8306)
- Naoya Sakamoto (ORCID: https://orcid.org/0000-0003-0061-059X)
- Goki Suda (ORCID: https://orcid.org/0000-0003-0098-9106)
- Qingjie Fu (ORCID: https://orcid.org/0000-0001-7460-8228)
- Masatsugu Ohara (ORCID: https://orcid.org/0000-0002-4366-3184)
- Risako Kohya
- Masaru Baba (ORCID: https://orcid.org/0000-0002-4142-3267)
- Tomoka Yoda
- Mitsuteru Natsuizaka (ORCID: https://orcid.org/0000-0002-1819-1955)
- Takashi Kitagataya
- Masato Nakai (ORCID: https://orcid.org/0000-0002-4860-1353)
- Takashi Sasaki (ORCID: https://orcid.org/0000-0001-7109-9835)
- Takuya Sho (ORCID: https://orcid.org/0000-0001-7943-3842)
- Koji Ogawa (ORCID: https://orcid.org/0000-0002-9221-6815)
- Minhu Chen (ORCID: https://orcid.org/0000-0003-2421-9966)
- Osamu Maehara
- Yoshiya Yamamoto
- Tomoe Kobayashi
- Sonoe Yoshida
- Ren Yamada
Institutions
- Sun Yat-sen University (CN)
- Hokkaido University (JP)
- Hokkaido Pharmaceutical University (JP)
- Kushiro Rosai Hospital (JP)
- Hokkaido hospital (JP)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Japan Community Healthcare Organization (JP)
- National Institute of Technology, Tomakomai College (JP)
- Hakodate National Hospital (JP)
Publication Details
- Journal
- Hepatology Research
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1111/hepr.14139
- Citations
- 6
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.22
Funders
- Japan Agency for Medical Research and Development