Loss of the Endothelial Glycocalyx Component EMCN Leads to Glomerular Impairment
Our study demonstrates a critical role of the endothelial marker EMCN in supporting normal glomerular filtration barrier structure and function by maintaining glomerular endothelial tight junction and homeostasis and podocyte function through endothelial-podocyte crosstalk.
Authors
- Eleftherios I. Paschalis (ORCID: https://orcid.org/0000-0002-4544-4452)
- Magali Saint‐Geniez (ORCID: https://orcid.org/0000-0001-9897-138X)
- Jie Liu (ORCID: https://orcid.org/0000-0003-4638-2713)
- Fengyang Lei (ORCID: https://orcid.org/0000-0002-9169-8314)
- Yin‐Shan Ng (ORCID: https://orcid.org/0000-0002-4982-1999)
- Ramon Bossardi Ramos (ORCID: https://orcid.org/0000-0001-8536-2606)
- Patrìcia A. D'Amore (ORCID: https://orcid.org/0000-0001-9652-8974)
- Issahy Cano (ORCID: https://orcid.org/0000-0001-9994-149X)
- Zhengping Hu (ORCID: https://orcid.org/0000-0001-7369-1314)
- H Gordon (ORCID: https://orcid.org/0009-0005-9561-5706)
Institutions
- Novartis (Switzerland) (CH)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- Albany Medical Center Hospital (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1161/circresaha.124.325218
- Citations
- 11
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.42
Funders
- Massachusetts General Hospital
- Harvard Stem Cell Institute