Epichaperome Inhibition by PU-H71-Mediated Targeting of HSP90 Sensitizes Glioblastoma Cells to Alkylator-Induced DNA Damage
These results confirm that HSP90 is a strong pro-survival factor in molecularly heterogeneous gliomas and suggest that epichaperome inhibition with HSP90 inhibitors warrants further investigation for the treatment of gliomas.
Authors
- Vinay K. Puduvalli (ORCID: https://orcid.org/0000-0001-8396-9500)
- Pratibha Sharma (ORCID: https://orcid.org/0000-0001-7070-3025)
- Jihong Xu (ORCID: https://orcid.org/0000-0002-1177-8315)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
Publication Details
- Journal
- Cancers
- Published
- 2024-11-24
- DOI
- https://doi.org/10.3390/cancers16233934
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Accenture
- Ohio State University
- University of Texas System
- University of Texas MD Anderson Cancer Center
- National Cancer Institute
- Moonshot Research and Development Program