Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma
FAK inhibitors are in combinatorial clinical testing with agents that prevent Ras-Raf-MAPK pathway activation in various cancers. This study suggests that nuclear FAK limits ERK/MAPK activation in supporting HGSOC cell survival to cisplatin stress. Overall, it is likely that targets of FAK-mediated survival signaling may be tumor type- and context-dependent.
Authors
- Douglas B. Flieder (ORCID: https://orcid.org/0000-0002-7422-4213)
- Xiao Lei Chen (ORCID: https://orcid.org/0000-0001-7998-9963)
- Denise C. Connolly (ORCID: https://orcid.org/0000-0003-0888-2004)
- Halime Meryem Soylu (ORCID: https://orcid.org/0000-0003-1088-624X)
- Antonia Boyer
- Maryam Abbas
- Dwayne G. Stupack (ORCID: https://orcid.org/0000-0003-4396-5745)
- Yichi Zhang (ORCID: https://orcid.org/0009-0003-3726-7243)
- Marjaana Ojalill (ORCID: https://orcid.org/0000-0003-3181-6742)
- Alfredo Molinolo (ORCID: https://orcid.org/0000-0001-8412-2889)
- David D. Schlaepfer (ORCID: https://orcid.org/0000-0003-4814-9210)
- Elise Tahon
- Michael McHale (ORCID: https://orcid.org/0000-0002-6471-362X)
- Marvin Xia
- Gaëtan Thivolle Lioux (ORCID: https://orcid.org/0009-0005-9146-0233)
Institutions
- Fox Chase Cancer Center (US)
- University of California San Diego (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0382
- Citations
- 7
- Primary Topic
- Ovarian cancer diagnosis and treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.76