Lenvatinib-activated NDUFA4L2/IL33/PADI4 pathway induces neutrophil extracellular traps that inhibit cuproptosis in hepatocellular carcinoma
Our study revealed that lenvatinib-induced NETs inhibited the cuproptosis of HCC cells, suggesting that targeting the IL33/PADI4/NET axis represents a promising therapeutic strategy for ameliorating lenvatinib resistance in HCC.
Authors
- Xiangbo Huang
- Lingyun Zhang (ORCID: https://orcid.org/0000-0001-5733-1810)
- Jian Gao (ORCID: https://orcid.org/0000-0002-2830-4810)
- Nan Yi
- Jilei Ma
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- Zhengzhou University (CN)
- Shanghai Cancer Institute (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1007/s13402-024-01013-w
- Citations
- 15
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.61