Aberrant basement membrane production by HSCs in MASLD is attenuated by the bile acid analog INT-767
These findings highlight the importance of basement membrane remodeling in MASH pathobiology and as a source of circulating biomarkers. Basement membrane deposition by activated HSCs is abrogated by INT-767 treatment and measurement of basement membrane molecules should be included when determining the therapeutic efficacy of FXR agonists.
Authors
- Prakash Ramachandran (ORCID: https://orcid.org/0000-0001-5996-2413)
- N Hartmann (ORCID: https://orcid.org/0000-0001-6041-8597)
- Anna M. Hoy (ORCID: https://orcid.org/0000-0002-0632-6744)
- Madara Brice (ORCID: https://orcid.org/0000-0002-0135-915X)
- Jia Li (ORCID: https://orcid.org/0000-0003-0100-417X)
- Elena F. Sutherland (ORCID: https://orcid.org/0000-0003-4636-6350)
- Denise Oró
- Diana Julie Leeming (ORCID: https://orcid.org/0000-0002-4256-140X)
- Luciano Adorini (ORCID: https://orcid.org/0000-0001-8109-339X)
- Eleni Papachristoforou (ORCID: https://orcid.org/0000-0003-1553-1405)
- M.A. Karsdal (ORCID: https://orcid.org/0000-0001-5026-8740)
- Frances Turner (ORCID: https://orcid.org/0000-0001-5951-0329)
- Neil O. Carragher (ORCID: https://orcid.org/0000-0001-5541-9747)
- Michael Feigh (ORCID: https://orcid.org/0000-0001-5274-8799)
- John A. Marwick
- Mette Juul Nielsen (ORCID: https://orcid.org/0000-0002-4448-8955)
- Timothy James Kendall (ORCID: https://orcid.org/0000-0002-4174-2786)
- Jonathan Andrew Fallowfield (ORCID: https://orcid.org/0000-0002-5741-1471)
- Jonathan D. Roth (ORCID: https://orcid.org/0000-0002-1983-385X)
- Mary Erickson (ORCID: https://orcid.org/0000-0002-6514-6073)
Institutions
- Edinburgh Cancer Research (GB)
- Gubra (Denmark) (DK)
- Edinburgh Genomics (GB)
- Nordic Bioscience (Denmark) (DK)
- Centre for Inflammation Research (GB)
- Intercept Pharmaceuticals (United States) (US)
- University of Edinburgh (GB)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1097/hc9.0000000000000574
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Medical Research Council