Aberrant basement membrane production by HSCs in MASLD is attenuated by the bile acid analog INT-767

These findings highlight the importance of basement membrane remodeling in MASH pathobiology and as a source of circulating biomarkers. Basement membrane deposition by activated HSCs is abrogated by INT-767 treatment and measurement of basement membrane molecules should be included when determining the therapeutic efficacy of FXR agonists.

Authors

Institutions

Publication Details

Journal
Hepatology Communications
Published
2024-11-25
DOI
https://doi.org/10.1097/hc9.0000000000000574
Citations
4
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
1.55

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Aberrant basement membrane production by HSCs in MASLD is attenuated by the bile acid analog INT-767

Prakash Ramachandran, N Hartmann, Anna M. Hoy, Madara Brice et al.
4 citations
Hepatology Communications
Liver Disease Diagnosis and Treatment
1.55
article

Aberrant basement membrane production by HSCs in MASLD is attenuated by the bile acid analog INT-767

Prakash Ramachandran, N Hartmann, Anna M. Hoy, Madara Brice, Jia Li, Elena F. Sutherland, Denise Oró, Diana Julie Leeming, Luciano Adorini, Eleni Papachristoforou, M.A. Karsdal, Frances Turner, Neil O. Carragher, Michael Feigh, John A. Marwick, Mette Juul Nielsen, Timothy James Kendall, Jonathan Andrew Fallowfield, Jonathan D. Roth, Mary Erickson
article en
4 citations

Abstract

These findings highlight the importance of basement membrane remodeling in MASH pathobiology and as a source of circulating biomarkers. Basement membrane deposition by activated HSCs is abrogated by INT-767 treatment and measurement of basement membrane molecules should be included when determining the therapeutic efficacy of FXR agonists.

Hepatology CommunicationsVol. 8(12)
Edinburgh Cancer Research (GB), Gubra (Denmark) (DK), Edinburgh Genomics (GB), Nordic Bioscience (Denmark) (DK), Centre for Inflammation Research (GB), Intercept Pharmaceuticals (United States) (US), University of Edinburgh (GB)
Medical Research Council
Good health and well-being
Openalex Percentile: Top 15%
Liver Disease Diagnosis and Treatment
1.55
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.