Overexpression of TNFα in TNF∆ARE+/− mice increases hepatic periportal inflammation and alters bile acid signaling in mice
Increased TNFα expression is sufficient to promote both intestinal and hepatobiliary inflammation and fibrotic injury and contributes to hepatic dysregulation of FXR signaling and bile acid homeostasis. Overall, these results suggest that the TNF∆ARE+/- mouse may be a useful model for studying chronic hepatic inflammation.
Authors
- Ronald J. Sokol (ORCID: https://orcid.org/0000-0001-7433-4095)
- Leigha D. Larsen
- David J. Orlicky (ORCID: https://orcid.org/0000-0002-0417-1400)
- Colin T. Shearn (ORCID: https://orcid.org/0000-0002-9618-9885)
- Sean P. Colgan (ORCID: https://orcid.org/0000-0003-0431-8887)
- Michael W. Devereaux (ORCID: https://orcid.org/0000-0003-0140-8756)
- Aimee L. Anderson (ORCID: https://orcid.org/0000-0002-2464-5343)
- Calen A. Steiner (ORCID: https://orcid.org/0000-0002-1964-010X)
- Lisa A. Spencer (ORCID: https://orcid.org/0000-0002-2365-9559)
- Samuel D. Koch
Institutions
- Children's Hospital Colorado (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1097/hc9.0000000000000589
- Citations
- 2
- Primary Topic
- Pediatric Hepatobiliary Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.15