AM-PAC 6-Clicks Basic Mobility and Daily Activities Scores Predict 90-Day Modified Rankin Score in Patients with Acute Ischemic Stroke Secondary to Large Vessel Occlusion

<b>Background:</b> The relative level of functional impairment in stroke patients is a significant determinant of post-acute care. The Activity Measure for Post Acute Care 6-Clicks (AM-PAC) scores for basic mobility and daily activity are rapid standardized assessments whose utilities in predicting long-term stroke outcomes have not yet been studied. <b>Methods:</b> We performed a retrospective analysis of acute ischemic stroke patients and their outcomes. We evaluated the distribution of outcomes using the chi-square test. We then compared the proportions of patients with good stroke outcomes for different combinations of favorable scores. We performed two-proportion z-tests to determine the significance, and <i>p</i> < 0.05 was considered significant. <b>Results:</b> 282 patients met all of the inclusion criteria between 12 January 2017 and 19 March 2023 (<i>M</i> age = 66.4, 59.9% female). After dichotomizing the scores as "favorable" vs. "unfavorable", we found that 128/155 (82.6%) patients with favorable basic mobility had good stroke outcomes vs. 20/127 (15.7%) with unfavorable basic mobility (<i>p</i> < 0.0001). Similarly, for favorable daily activity, it was 103/113 (91.2%) vs. 45/169 (26.6%), for both favorable, it was 100/109 (91.7%) vs. 48/173 (27.7%), and for neither favorable, it was 17/123 (13.8%) vs. 131/159 (82.4%), all with <i>p</i> < 0.0001. When comparing among groups, both favorable patients differed significantly from those with favorable basic mobility alone (<i>p</i> = 0.033) but not those with favorable daily activity alone (<i>p</i> = 0.875). Even after adjusting for age, the odds ratios of favorable scores were greater than 20 for any combination (<i>p</i> < 0.001). <b>Conclusions:</b> Basic mobility and daily activity AM-PAC scores at discharge are independent predictors of anterior circulation acute ischemic stroke outcomes at 90 days.