Intestine epithelial–specific hypoxia-inducible factor-1α overexpression ameliorates western diet–induced MASLD
Our data provide evidence that pharmacological or genetic activation of intestinal HIF-1α markedly ameliorates western diet-induced metabolic dysfunction-associated steatotic liver disease in a sex-dependent manner. The underlying mechanism is likely attributed to HIF-1α activation-induced upregulation of glycolysis, which, in turn, leads to enhanced epithelial cell proliferation and augmented gut barrier function.
Authors
- Craig J. McClain (ORCID: https://orcid.org/0000-0002-7219-8939)
- Eric C. Rouchka (ORCID: https://orcid.org/0000-0003-3487-6572)
- Bradford G. Hill (ORCID: https://orcid.org/0000-0001-5332-8286)
- Ming Song (ORCID: https://orcid.org/0000-0001-8459-6953)
- Xiaohong Li (ORCID: https://orcid.org/0000-0001-8345-9164)
- Madison S. Taylor (ORCID: https://orcid.org/0000-0001-6810-1105)
- Manman Xu (ORCID: https://orcid.org/0000-0002-7002-4978)
Institutions
- University of Louisville (US)
- Louisville VA Medical Center (US)
- Beijing YouAn Hospital (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1097/hc9.0000000000000572
- Citations
- 4
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- American Heart Association
- James Graham Brown Foundation
- University of Louisville
- National Institutes of Health
- National Institute of General Medical Sciences