Utility of Papilledema for Detection of Elevated Intracranial Pressure in Craniosynostosis

Papilledema is swelling of the optic disk due to fluid accumulation around the optic nerve and is commonly used to detect increased intracranial (ICP) in craniosynostosis. This study aimed to assess the prevalence and utility of papilledema detection in patients with single-suture, multi-suture, and syndromic craniosynostosis and the differences before and after surgical intervention. A retrospective review of ophthalmology examinations of patients diagnosed with craniosynostosis treated between 2008 and 2023 was performed. Demographics, diagnosis, and operative data were collected. A total of 1509 ophthalmology exams of 519 patients were reviewed. The overall rate of papilledema in patients with craniosynostosis was 2.12%. The single-suture and multi-suture involvement rates were 1.15% and 5.81%, respectively. Non-syndromic patients with preoperative and postoperative examinations had an overall rate of 3.13%. Most had single suture involvement, and the average age of papilledema examination was 72 months. Syndromic patients with preoperative and postoperative examinations had an overall rate of 17.65%. The majority had multiple suture involvement, and the average age of papilledema examination was 26 months. The overall papilledema detection rate was low in patients with craniosynostosis. Multi-suture involvement and syndromic diagnosis had increased rates of papilledema. The average age of diagnosis was in older children. Syndromic patients had papilledema examination at a younger age. The authors' findings support the concept that fundoscopic ophthalmologic examination will benefit patients with multi-suture involvement, an associated syndrome, and older age.