Incident rheumatoid arthritis in patients living in Turkey and in Denmark: a comparative clinical, genetic, and serological study
This study substantiates the north-south gradient hypothesis, highlighting that new-onset RA patients in Denmark tend to experience an older age of onset and more severe disease activity than their Turkish counterparts. Variations in risk-enhancing alleles and fewer risk-protective alleles in Danish patients and controls are associated with these distinctions. Future research should investigate the genetic and environmental factors underlying these regional disparities, exploring their persistence in the long-term course of the disease through follow-up studies.
Authors
- Claus Rasmussen (ORCID: https://orcid.org/0000-0001-8543-8447)
- Servet Akar (ORCID: https://orcid.org/0000-0002-3734-1242)
- Dilek Solmaz (ORCID: https://orcid.org/0000-0002-9035-689X)
- Niels Steen Krogh (ORCID: https://orcid.org/0000-0002-8520-1674)
- Nurullah Akkoç (ORCID: https://orcid.org/0000-0002-3718-171X)
- Belkıs Nihan Coşkun (ORCID: https://orcid.org/0000-0003-0298-4157)
- G. Kenar (ORCID: https://orcid.org/0000-0002-0485-1369)
- Karen B. Lauridsen (ORCID: https://orcid.org/0000-0003-2187-8288)
- Handan Yarkan Tuğsal (ORCID: https://orcid.org/0000-0003-0633-790X)
- G. Can (ORCID: https://orcid.org/0000-0001-8347-0873)
- Rudi Steffensen (ORCID: https://orcid.org/0000-0002-2080-1177)
- Fatoş Önen (ORCID: https://orcid.org/0000-0002-6341-2622)
- Yavuz Pehlivan (ORCID: https://orcid.org/0000-0002-1201-8836)
- Nevsun İnanç (ORCID: https://orcid.org/0000-0003-2862-0562)
Institutions
- Synlab Czech (Czechia) (CZ)
- Bursa Uludağ Üni̇versi̇tesi̇ (TR)
- Dokuz Eylül University (TR)
- Izmir Kâtip Çelebi University (TR)
- Aalborg University Hospital (DK)
- Glostrup Hospital (DK)
- Rigshospitalet (DK)
- North Denmark Region (DK)
- Marmara University (TR)
Publication Details
- Journal
- Scandinavian Journal of Rheumatology
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1080/03009742.2024.2424083
- Citations
- 1
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.47