Deficiency of miR-155 in Leukemic B-Cells Results in Cell Cycle Arrest and Deregulation of MIR155HG/TP53INP1/CDKN1A/CCND1 network
We demonstrate that miR-155 deficiency impairs cell proliferation, cell cycle, transcriptome, and miRNome via deregulation of the MIR155HG/TP53INP1/CDKN1A/CCND1 axis. Our CLL model is valuable for further studies to manipulate miRNA levels to revert highly aggressive leukemic cells to nearly benign or non-leukemic types.
Authors
- Tomáš Stopka (ORCID: https://orcid.org/0000-0001-7236-6894)
- Martin Báječný (ORCID: https://orcid.org/0000-0002-3028-8055)
- O. Yu. Yurikova
- Filipp Savvulidi (ORCID: https://orcid.org/0000-0002-4889-837X)
- Luděk Šefc (ORCID: https://orcid.org/0000-0003-2846-220X)
- René Lenobel (ORCID: https://orcid.org/0000-0001-7387-0056)
- Karina Vargová (ORCID: https://orcid.org/0000-0002-4969-4133)
- Marek Šebela (ORCID: https://orcid.org/0000-0001-9835-1375)
- Juraj Kokavec (ORCID: https://orcid.org/0000-0003-0267-4570)
- Jörg Tost (ORCID: https://orcid.org/0000-0002-2683-0817)
- Radim Simerský (ORCID: https://orcid.org/0000-0002-4481-6680)
- Zuzana Zemanová (ORCID: https://orcid.org/0000-0002-7538-6601)
- Vı́t Herynek (ORCID: https://orcid.org/0000-0002-1775-2394)
- Dmitry Kazantsev
- Elena A. Golovina (ORCID: https://orcid.org/0000-0002-3192-2521)
- Pavel Klener (ORCID: https://orcid.org/0000-0001-7786-9378)
Institutions
- Al-Farabi Kazakh National University (KZ)
- Czech University of Life Sciences Prague (CZ)
- Charles University (CZ)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Centre National de Recherche en Génomique Humaine (FR)
- Direction de la Recherche Fondamentale (FR)
- CEA Paris-Saclay (FR)
- Czech Academy of Sciences, Institute of Experimental Botany (CZ)
- General University Hospital in Prague (CZ)
- Palacký University Olomouc (CZ)
Publication Details
- Journal
- Archives of Medical Research
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1016/j.arcmed.2024.103124
- Citations
- 6
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.71