Potassium <i>tert</i>‐Butoxide‐Mediated Ring‐Opening of Indolines: Concise Synthesis of 2‐Vinylanilines
Abstract A concise and metal‐free procedure has been developed for the synthesis of 2‐vinylanilines. Reactions of indolines with tert ‐BuOK in DMSO afford the decorated 2‐vinylanilines in yields up to 92 %. In addition, the 2, or 3‐substituted indolines could be converted to trisubstituted alkenes. Also, the protocol can be scaled to afford gram quantities of the decorated 2‐vinylanilines.
Authors
- Keisuke Tokushige (ORCID: https://orcid.org/0009-0009-6814-3693)
- Takumi Abe (ORCID: https://orcid.org/0000-0003-1729-1097)
- Shota Asai (ORCID: https://orcid.org/0000-0001-7346-6213)
Institutions
- Shujitsu University (JP)
- Okayama University (JP)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1002/ajoc.202400552
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00