A glioneuronal tumor with neurocytic rosettes harboring <scp>FGFR1</scp> internal tandem duplication – A report of a unique case
Rosette-forming glioneuronal tumors (RGNTs) with FGFR1 tyrosine kinase domain internal tandem duplication (FGFR1 ITD) is exceedingly rare, with only a few cases reported in the literature. Hereby we present a case of a tumor with RGNT morphology occurring in area of septum pellucidum of 43-year-old male. The tumor showed FGFR1 ITD, no PIK3CA, PIK3R1 or NF1 alterations and inconclusive methylation profile with match for class of "low-grade glial/glioneuronal/neuroepithelial tumors". No areas characteristic of dysembryoplastic neuroepithelial tumor were identified. A brief review of literature on discrepancies between morphological diagnosis of RGNT and molecular profile of the entity is provided.
Authors
- David Netuka (ORCID: https://orcid.org/0000-0001-8609-4789)
- Martin Májovský (ORCID: https://orcid.org/0000-0001-7725-5181)
- Marián Švajdler (ORCID: https://orcid.org/0000-0001-8052-4741)
- Nikola Hájková (ORCID: https://orcid.org/0000-0002-1683-7783)
- Jiří Soukup
- Veronika Hájková (ORCID: https://orcid.org/0009-0001-5514-2327)
Institutions
- Charles University (CZ)
- Biopticka Laborator (Czechia) (CZ)
- Military University Hospital Prague (CZ)
- University Hospital Hradec Králové (CZ)
- General University Hospital in Prague (CZ)
Publication Details
- Journal
- Neuropathology
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1111/neup.13018
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Univerzita Karlova v Praze
- Ministerstvo Obrany České Republiky