Rapidly Progressive Idiopathic Pyoderma Gangrenosum in a Pediatric Patient Successfully Treated With Infliximab
Pyoderma gangrenosum (PG) is a rare skin disorder with poorly understood pathophysiology. PG infrequently occurs in children, and approximately 4% of patients with PG are infants and children. First line therapy is topical and systemic corticosteroids, which typically yields rapid response. We report a case of rapidly progressive pediatric PG of unknown inciting cause that ultimately required multi-modal therapy with systemic and topical corticosteroids, high-dose infliximab, and colchicine.
Authors
- Melissa A. Lerman (ORCID: https://orcid.org/0000-0003-1378-5292)
- Nikhita Perry (ORCID: https://orcid.org/0009-0000-1959-9090)
- Robert J. Smith (ORCID: https://orcid.org/0000-0001-9746-1230)
- Robert Duffy (ORCID: https://orcid.org/0000-0001-8956-6390)
- Mary Larijani (ORCID: https://orcid.org/0000-0002-3824-302X)
- Marissa J. Perman (ORCID: https://orcid.org/0000-0002-6780-8157)
- Maria Queenan
- Stephanie Wang (ORCID: https://orcid.org/0000-0003-4899-7658)
Institutions
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Pediatric Dermatology
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1111/pde.15828
- Citations
- 1
- Primary Topic
- Autoimmune and Inflammatory Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.39