Fc-Afucosylation of VAR2CSA-Specific Immunoglobulin G and Clinical Immunity to Placental <i>Plasmodium falciparum</i> Malaria
Fc-afucosylated VAR2CSA-specific IgG effectively induced NK-cell degranulation and was associated with protection against LBW, independent of IgG levels. Our study has implications for the development of VAR2CSA-based subunit vaccines, which exclusively induce Fc-fucosylated IgG.
Authors
- Gestur Vidarsson (ORCID: https://orcid.org/0000-0001-5621-003X)
- Firmine Viwami (ORCID: https://orcid.org/0009-0001-0542-3171)
- Tonći Šuštić (ORCID: https://orcid.org/0000-0003-0559-6803)
- Mads Delbo Larsen (ORCID: https://orcid.org/0000-0002-1985-5901)
- Nicaise Tuikue Ndam (ORCID: https://orcid.org/0000-0003-2646-2513)
- Paulina Ampomah (ORCID: https://orcid.org/0000-0002-8863-7449)
- Mary Lopez-Perez (ORCID: https://orcid.org/0000-0002-9876-0248)
- Manfred Wuhrer (ORCID: https://orcid.org/0000-0002-0814-4995)
- Michael F. Ofori (ORCID: https://orcid.org/0000-0003-2341-7514)
- Lars Hviid (ORCID: https://orcid.org/0000-0002-1698-4927)
Institutions
- University of Copenhagen (DK)
- University of Cape Coast (GH)
- University of Ghana (GH)
- Utrecht University (NL)
- Leiden University Medical Center (NL)
- Rigshospitalet (DK)
- Sanquin (NL)
- Noguchi Memorial Institute for Medical Research (GH)
- Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (FR)
- Netherlands Metabolomics Centre (NL)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1093/infdis/jiae529
- Citations
- 4
- Primary Topic
- Complement system in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.96
Funders
- University of Minnesota
- Landsteiner Foundation for Blood Transfusion Research
- Universiteit Leiden
- Leids Universitair Medisch Centrum
- Danmarks Frie Forskningsfond
- Seventh Framework Programme
- Danish International Development Agency