Inhibition of soluble epoxide hydrolase reverses bone loss in periodontitis by upregulating EMCN and inhibiting osteoclasts
TPPU promotes local regeneration in periodontitis by inhibiting inflammation and bone resorption. Thus, targeting soluble epoxide hydrolase represents an endogenous regenerative strategy for periodontitis treatment.
Authors
- Ni Kou (ORCID: https://orcid.org/0000-0003-3622-4228)
- Yanrong Zhao (ORCID: https://orcid.org/0000-0003-0539-6852)
- Fu Wang (ORCID: https://orcid.org/0000-0001-9615-1038)
- Juanjuan Li (ORCID: https://orcid.org/0000-0002-0074-1453)
- Xueping Yang (ORCID: https://orcid.org/0000-0001-9819-3960)
- Xiaoli Shi (ORCID: https://orcid.org/0000-0003-3171-5984)
- Jie Zhao (ORCID: https://orcid.org/0000-0002-1880-2293)
- Weixian Chen (ORCID: https://orcid.org/0009-0003-0595-0523)
- Lingwenyao Kong
Institutions
- Dalian Medical University (CN)
- Jinan Stomatological Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1186/s13287-024-04054-y
- Citations
- 5
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Natural Science Foundation of China
- Department of Education of Liaoning Province