Rapid and non-invasive analysis of paracetamol overdose using paper arrow-mass spectrometry: a prospective observational study
Paracetamol detection from SS with PA-MS provides a reliable result that can aid timely treatment decisions. Differences between paracetamol concentration in resting and stimulated saliva were also identified for the first time, highlighting the importance of standardising saliva collection methods in general. This study marks a major milestone towards rapid and convenient saliva analysis.
Authors
- A. Malcolm Gill (ORCID: https://orcid.org/0000-0002-8198-1028)
- K Landa
- Philip Arnold (ORCID: https://orcid.org/0000-0002-6606-351X)
- Gabrielle Seddon
- Daniel B. Hawcutt (ORCID: https://orcid.org/0000-0002-8120-6507)
- Laura Walker (ORCID: https://orcid.org/0000-0001-8478-0259)
- Tung-Ting Sham (ORCID: https://orcid.org/0000-0002-9648-4964)
- Jennie Craske (ORCID: https://orcid.org/0000-0003-0506-1569)
- Simon Maher (ORCID: https://orcid.org/0000-0002-0594-6976)
- Barry L. Smith (ORCID: https://orcid.org/0000-0001-5571-3647)
- Ionela Grasim
- Silothabo Dliso (ORCID: https://orcid.org/0000-0003-3125-441X)
- Andrew Davison (ORCID: https://orcid.org/0000-0001-5501-4475)
- Louise Bracken (ORCID: https://orcid.org/0000-0002-9632-2252)
- Tao Chen (ORCID: https://orcid.org/0000-0002-5489-6450)
- Yufeng Zhou (ORCID: https://orcid.org/0000-0002-8055-9642)
Institutions
- University of Liverpool (GB)
- Liverpool School of Tropical Medicine (GB)
- Royal Liverpool University Hospital (GB)
- Alder Hey Children's NHS Foundation Trust (GB)
- Alder Hey Children's Hospital (GB)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1186/s12916-024-03776-3
- Citations
- 3
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Alder Hey Children's NHS Foundation Trust
- National Institute for Health and Care Research
- Department of Health and Social Care
- Engineering and Physical Sciences Research Council
- Research England