Overcoming GABA-Induced Treg Suppression of Immunity by ABAT to Augment CD8<sup>+</sup>T Cell Antitumor Immune Response in Liver Cancer
ABAT functions to inhibit Treg differentiation in liver cancer through downregulation of GABA, thus promoting the antitumor activity of CD8+T cells.
Authors
- Weirui Zhang (ORCID: https://orcid.org/0000-0002-4048-392X)
- Jianwen Zhan
- Weisen Lin (ORCID: https://orcid.org/0009-0000-4812-6815)
- Yandi Lu (ORCID: https://orcid.org/0009-0000-5302-5525)
- Gengzhen Chen (ORCID: https://orcid.org/0000-0001-9265-4359)
- Shugen Xu (ORCID: https://orcid.org/0000-0002-7113-4925)
- Binbin Gu
- Hui Han
Institutions
- Wenzhou Medical University (CN)
- Zhejiang Taizhou Hospital (CN)
Publication Details
- Journal
- International Archives of Allergy and Immunology
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1159/000542404
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.31