Pediatric Traumatic Brain Injury and Microvascular Blood-Brain Barrier Pathology
This autopsy case series of patients dying in the acute phase after single moderate or severe TBI provides neuropathological evidence of age-dependent differences in vascular pathology. Specifically, although BBB disruption in pediatric material was typically confined to microvascular, capillary-level vessels, in adult case material, BBB disruption more typically involved larger-diameter vessels. This observation of distinct microvascular pathology in pediatric acute TBI requires further investigation. In the meantime, this study presents an intriguing potential candidate pathology contributing to diffuse brain swelling in this age group.
Authors
- William Stewart (ORCID: https://orcid.org/0000-0003-2199-2582)
- Douglas H. Smith (ORCID: https://orcid.org/0000-0002-0813-421X)
- Josie Fullerton (ORCID: https://orcid.org/0000-0002-1967-9522)
- Jennifer Hay (ORCID: https://orcid.org/0000-0001-9973-4992)
- J. H. Atkinson
- Charlotte Bryant-Craig
Institutions
- The Francis Crick Institute (GB)
- NHS Lanarkshire (GB)
- Queen Elizabeth University Hospital (GB)
- University of Glasgow (GB)
- University of Pennsylvania (US)
- University of Edinburgh (GB)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.46767
- Citations
- 15
- Primary Topic
- Traumatic Brain Injury and Neurovascular Disturbances
- Type
- article
- Field-Weighted Citation Impact
- 5.54
Funders
- U.S. Department of Defense
- Glasgow Children’s Hospital Charity
- National Institutes of Health