Metabolic Characteristics of Sclera in Lens-Induced Myopic Guinea Pigs
Several amino acids, including glycine, l-isoleucine, l-serine, and l-valine, were significantly reduced in the myopic sclera, along with a marked downregulation of amino acid and pyrimidine metabolism pathways. Glycine supplementation can increase COL1A1 content and inhibit myopia progression by reducing ferroptosis within the sclera, suggesting that glycine could serve as a potential therapeutic intervention for myopia.
Authors
- Changyue Zheng
- Chenli Feng (ORCID: https://orcid.org/0000-0002-8533-1962)
- Jinhui Dai
- Shichu Liu (ORCID: https://orcid.org/0009-0002-4991-8376)
- Hao Li (ORCID: https://orcid.org/0000-0002-2125-9092)
- Qianhong Feng (ORCID: https://orcid.org/0009-0002-4463-2985)
- Jing Cong (ORCID: https://orcid.org/0000-0002-1544-7097)
- Xueqi Lin (ORCID: https://orcid.org/0000-0001-6995-4679)
- Jiayue Yuan (ORCID: https://orcid.org/0009-0007-2664-8146)
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- YangPu Geriatric Hospital (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1167/iovs.65.13.51
- Citations
- 2
- Primary Topic
- Ophthalmology and Visual Impairment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.77