PIEZO1 attenuates Marfan syndrome aneurysm development through TGF-β signaling pathway inhibition via TGFBR2
Piezo1 deficiency aggravates MFS aneurysms by promoting TGF-β signalling pathway activation via TGF-β receptor 2 endocytosis and a decrease in autophagy. These data suggest that PIEZO1 may be a potential therapeutic target for MFS treatment.
Authors
- Jiahong Xia (ORCID: https://orcid.org/0000-0003-2144-7525)
- Lang Jiang (ORCID: https://orcid.org/0000-0002-1838-1900)
- Xiaoyue Xiao
- Hao Liu (ORCID: https://orcid.org/0000-0001-6918-7510)
- S.-G. Wang (ORCID: https://orcid.org/0000-0002-8738-403X)
- Shanshan Chen (ORCID: https://orcid.org/0000-0001-9723-2403)
- Ping Ye (ORCID: https://orcid.org/0000-0002-5591-6812)
- Peiwen Yang (ORCID: https://orcid.org/0000-0002-4351-3151)
- Sheng Le
Institutions
- Central South University (CN)
- Central Hospital of Wuhan (CN)
- Xiangya Hospital Central South University (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- European Heart Journal
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1093/eurheartj/ehae786
- Citations
- 17
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- National Natural Science Foundation of China