The Prognostic Significance of CD47, CD68, and CD163 Expression Levels and Their Relationship with MLR and MAR in Locally Advanced and Oligometastatic Nasopharyngeal Carcinoma

CD47, CD68, and CD163 are significant prognostic markers in NPC, with higher levels being associated with poorer OS and PFS. Elevated MLR and MAR values also predict worse outcomes, underscoring their value as prognostic tools. CD163 and MLR are particularly strong predictors, highlighting the crucial role of TAMs in NPC management and suggesting that CD163 is a potential therapeutic target within the immune checkpoint pathway.

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Publication Details

Journal
Diagnostics
Published
2024-11-24
DOI
https://doi.org/10.3390/diagnostics14232648
Citations
1
Primary Topic
Phagocytosis and Immune Regulation
Type
article
Field-Weighted Citation Impact
0.24
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article

The Prognostic Significance of CD47, CD68, and CD163 Expression Levels and Their Relationship with MLR and MAR in Locally Advanced and Oligometastatic Nasopharyngeal Carcinoma

Murat Koçer, Ramazan Oğuz Yüceer, Şenay Yıldırım, Erkan Kayıkçıoğlu et al.
1 citations
Diagnostics
Phagocytosis and Immune Regulation
0.24
article

The Prognostic Significance of CD47, CD68, and CD163 Expression Levels and Their Relationship with MLR and MAR in Locally Advanced and Oligometastatic Nasopharyngeal Carcinoma

Murat Koçer, Ramazan Oğuz Yüceer, Şenay Yıldırım, Erkan Kayıkçıoğlu, Asım Armağan Aydın, Ahmet Ünlü
article en
1 citations

Abstract

CD47, CD68, and CD163 are significant prognostic markers in NPC, with higher levels being associated with poorer OS and PFS. Elevated MLR and MAR values also predict worse outcomes, underscoring their value as prognostic tools. CD163 and MLR are particularly strong predictors, highlighting the crucial role of TAMs in NPC management and suggesting that CD163 is a potential therapeutic target within the immune checkpoint pathway.

DiagnosticsVol. 14(23)
Sivas Cumhuriyet Üniversitesi (TR), Istinye University (TR), Sağlık Bilimleri Üniversitesi (TR), Liv Hospital (TR)
Good health and well-being
Openalex Percentile: Top 40%
Phagocytosis and Immune Regulation
0.24
DOIOpen Access PDFOpenAlex
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The Prognostic Significance of CD47, CD68, and CD163 Expression Levels and Their Relationship with MLR and MAR in Locally Advanced and Oligometastatic Nasopharyngeal Carcinoma — Murat Koçer, Ramazan Oğuz Yüceer, et al. · Diagnostics (2024) | TGRS Research Map | TGRS