Extrachromosomal circular DNA containing DTX1 promotes cell growth in hydroquinone-induced malignantly transformed cells by regulating the transcription of DTX1
EccDNA_DTX1 promotes cell growth in hydroquinone-induced malignantly transformed cells by regulating the transcription of DTX1 and ferroptosis. This study profiles eccDNA characteristics and defines the role and mechanism of eccDNA_DTX1 for the first time, shedding new light on the relationship between eccDNAs and carcinogenesis.
Authors
- Jiheng Qin (ORCID: https://orcid.org/0000-0003-0803-2843)
- Bohuan Zhong
- Jinxue Meng
- Yongdui Ruan (ORCID: https://orcid.org/0000-0001-7376-814X)
- Gongda Zhang
- Yali Han (ORCID: https://orcid.org/0000-0003-4533-922X)
- Linhua Liu (ORCID: https://orcid.org/0000-0002-2652-0130)
- Xiaoxuan Ling
- He Zhang (ORCID: https://orcid.org/0000-0001-9954-4451)
- Fan Zhu (ORCID: https://orcid.org/0000-0003-3817-4674)
- Jialong Chen (ORCID: https://orcid.org/0000-0001-5040-0692)
- Daifan Lin (ORCID: https://orcid.org/0000-0001-9957-4968)
- Qian Jiao (ORCID: https://orcid.org/0009-0003-0576-8297)
Institutions
- Guangdong Medical College (CN)
- Dongguan University of Technology (CN)
- Dongguan People’s Hospital (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1186/s12885-024-13177-7
- Citations
- 2
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province