Latent mechanisms of language disorganization relate to specific dimensions of psychopathology

Comprehensible communication is critical for social functioning and well-being. In psychopathology, incoherent discourse is assumed to reflect disorganized thinking, which is classically linked to psychotic disorders. However, people do not express everything that comes to mind, rendering inferences from discourse to the underlying structure of thought challenging. Indeed, a range of psychopathologies are linked to self-reported disorganized thinking in the absence of language output incoherence. Here we combine natural language processing and computational modeling of free association to detail the relationship between disorganized thinking and language (in)coherence in a large sample of participants varying across different dimensions of psychopathology. Our approach allowed us to differentiate between disorganized thinking, disinhibited thought expression and deliberate creativity. We find evidence for both under-regulated and over-regulated disorganized thinking, which relate to two specific dimensions of psychopathology: self-reported eccentricity and suspiciousness. Broadly, these results underscore the theoretical progress afforded by analyzing latent dimensions underlying behavior and psychopathology.

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Publication Details

Journal
Nature Mental Health
Published
2024-11-25
DOI
https://doi.org/10.1038/s44220-024-00351-w
Citations
3
Primary Topic
Neurobiology of Language and Bilingualism
Type
article
Field-Weighted Citation Impact
1.03

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article

Latent mechanisms of language disorganization relate to specific dimensions of psychopathology

Noam Siegelman, Raymond J. Dolan, Rick A. Adams, Isaac Fradkin et al.
3 citations
Nature Mental Health
Neurobiology of Language and Bilingualism
1.03
article

Latent mechanisms of language disorganization relate to specific dimensions of psychopathology

Noam Siegelman, Raymond J. Dolan, Rick A. Adams, Isaac Fradkin, Rani Moran
article en
3 citations

Abstract

Comprehensible communication is critical for social functioning and well-being. In psychopathology, incoherent discourse is assumed to reflect disorganized thinking, which is classically linked to psychotic disorders. However, people do not express everything that comes to mind, rendering inferences from discourse to the underlying structure of thought challenging. Indeed, a range of psychopathologies are linked to self-reported disorganized thinking in the absence of language output incoherence. Here we combine natural language processing and computational modeling of free association to detail the relationship between disorganized thinking and language (in)coherence in a large sample of participants varying across different dimensions of psychopathology. Our approach allowed us to differentiate between disorganized thinking, disinhibited thought expression and deliberate creativity. We find evidence for both under-regulated and over-regulated disorganized thinking, which relate to two specific dimensions of psychopathology: self-reported eccentricity and suspiciousness. Broadly, these results underscore the theoretical progress afforded by analyzing latent dimensions underlying behavior and psychopathology.

Nature Mental HealthVol. 2(12)
Wellcome Centre for Human Neuroimaging (GB), Queen Mary University of London (GB), Hebrew University of Jerusalem (IL), University College London (GB)
Wellcome, Wellcome Trust, National Institute for Health and Care Research, European Commission, Max-Planck-Gesellschaft, University College London Hospitals NHS Foundation Trust, Horizon 2020 Framework Programme, Medical Research Council, Engineering and Physical Sciences Research Council
Quality Education
Openalex Percentile: Top 23%
Neurobiology of Language and Bilingualism
1.03
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