New players and targets in mannose 6-phosphate-dependent lysosomal sorting

The Golgi apparatus serves multiple crucial roles in the cell. These roles include the addition and subsequent modification of glycans, not only to newly-made proteins arriving from the endoplasmic reticulum, but also to precursors during the biosynthesis of glycolipids. New research by Brauer et al, (2024) now provides a conceptual framework that connects the use of glycosylation as a protein targeting signal with its use as a marker for Golgi quality control. A new study shows how a Golgi-resident protein is sent to the lysosome for degradation.