Spatial differences in gene expression across the dorsal raphe nucleus in a model of early Alzheimer's disease
<i>Map2k3os</i> may serve regulatory roles relevant for tau phosphorylation and warrants further investigation to characterize its interactions. Overall, this report demonstrates the power of large-scale spatial transcriptomics technologies, while underscoring the need for convergent-data validation to overcome their limitations.
Authors
- Louis John Kolling (ORCID: https://orcid.org/0000-0003-0597-0199)
- Catherine A. Marcinkiewcz (ORCID: https://orcid.org/0000-0001-7161-7815)
- Michael S. Chimenti (ORCID: https://orcid.org/0000-0002-4433-9976)
Institutions
- University of Iowa (US)
Publication Details
- Journal
- Journal of Alzheimer s Disease
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1177/13872877241299119
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- Roy J. Carver Charitable Trust
- Roy J. and Lucille A. Carver College of Medicine, University of Iowa
- National Institute on Aging