Culture-negative sepsis may be a different entity from culture-positive sepsis: a prospective nationwide multicenter cohort study
In patients with septic shock, culture-negativity was associated with increased mortality, despite the paradoxically higher appropriateness of empirical antibiotics than culture-positive patients. These contradictory findings suggest that the current criteria for determining the appropriateness of empirical antibiotic therapy may not be valid for culture-negative sepsis.
Authors
- Jeongwon Heo (ORCID: https://orcid.org/0000-0001-7694-6730)
- Gil Myeong Seong (ORCID: https://orcid.org/0000-0002-0765-8273)
- Jae Young Moon (ORCID: https://orcid.org/0000-0001-8724-6289)
- Song‐I Lee (ORCID: https://orcid.org/0000-0001-8372-4511)
- Suk‐Kyung Hong (ORCID: https://orcid.org/0000-0001-5698-0122)
- Mi Hyeon Park (ORCID: https://orcid.org/0000-0002-7710-0240)
- Heung Bum Lee (ORCID: https://orcid.org/0000-0002-8267-8434)
- Tai Sun Park (ORCID: https://orcid.org/0000-0001-7383-7934)
- Su Hwan Lee (ORCID: https://orcid.org/0000-0002-3487-2574)
- Young‐Jae Cho (ORCID: https://orcid.org/0000-0001-6943-4462)
- Hyung Koo Kang (ORCID: https://orcid.org/0000-0001-9671-0944)
- Ryoung‐Eun Ko (ORCID: https://orcid.org/0000-0003-4945-5623)
- Dong‐gon Hyun (ORCID: https://orcid.org/0000-0001-5434-2223)
- Kyung Chan Kim
- Youjin Chang (ORCID: https://orcid.org/0000-0002-4838-466X)
- Sung Yoon Lim (ORCID: https://orcid.org/0000-0003-3161-8711)
- Gee Young Suh (ORCID: https://orcid.org/0000-0001-5473-1712)
- Ju Hyun Oh (ORCID: https://orcid.org/0000-0003-0756-3810)
- Jae Myeong Lee (ORCID: https://orcid.org/0000-0001-5494-0653)
- Woo Hyun Cho (ORCID: https://orcid.org/0000-0002-8299-8008)
- Sang‐Bum Hong (ORCID: https://orcid.org/0000-0003-2737-7695)
- Sang‐Min Lee (ORCID: https://orcid.org/0000-0002-1388-9318)
- Yeon Joo Lee (ORCID: https://orcid.org/0000-0001-7697-4272)
- Eun Young Choi (ORCID: https://orcid.org/0000-0003-2974-5447)
- Su Yeon Lee (ORCID: https://orcid.org/0000-0003-1993-7752)
- Sang Hyun Kwak (ORCID: https://orcid.org/0000-0001-6077-2086)
- Jong‐Joon Ahn
- Dong Kyu Oh
- Chae-Man Lim
Institutions
- Ulsan College (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
- Inje University Sanggye Paik Hospital (KR)
Publication Details
- Journal
- Critical Care
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1186/s13054-024-05151-3
- Citations
- 10
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.87
Funders
- Seoul National University Bundang Hospital
- Korea Disease Control and Prevention Agency
- Hanyang University
- Catholic University of Daegu
- Jeju National University
- Chonnam National University
- Chungnam National University
- Kangwon National University
- Pusan National University
- Seoul National University
- Hallym University
- Inje University
- Korea University
- Yeungnam University
- Seoul National University Hospital
- Chungnam National University Hospital
- Jeju National University Hospital
- Jeonbuk National University
- Korea University Anam Hospital
- Samsung
- Ulsan University Hospital