Integrating multi-omics techniques and in vitro experiments reveals that GLRX3 regulates the immune microenvironment and promotes hepatocellular carcinoma cell proliferation and invasion through iron metabolism pathways
This study highlights the critical role of iron metabolism in the progression of hepatocellular carcinoma, particularly the regulatory mechanism of the GLRX3 gene in tumor cell proliferation and immune evasion. Iron metabolism abnormalities are not only drivers of liver cancer development but also key indicators of patient prognosis.
Authors
- Yang Li (ORCID: https://orcid.org/0000-0001-8718-353X)
- Ying Zhao (ORCID: https://orcid.org/0000-0002-3556-3300)
- Yunsheng Fang (ORCID: https://orcid.org/0000-0003-2213-0167)
- Xiaoyuan Qiao
- Yang Zhang (ORCID: https://orcid.org/0000-0002-8113-3870)
- Yuan Chen (ORCID: https://orcid.org/0000-0001-8799-7664)
- Ling Wu
- Danqiong Wang
Institutions
- Shanxi Medical University (CN)
- Shanxi Academy of Medical Sciences (CN)
- Tongji Hospital (CN)
- Taiyuan University of Science and Technology (CN)
- Huazhong University of Science and Technology (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-25
- DOI
- https://doi.org/10.3389/fimmu.2024.1496886
- Citations
- 4
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.68