Immune Signatures of Solid Tumor Patients Treated With Immune Checkpoint Inhibitors: An Observational Study
Our study elucidated the characteristics of different lymphocyte subsets in the peripheral blood of solid tumor patients. Further research revealed changes in the phenotypes of different lymphocyte subsets after ICIs treatment, with the activated phenotype of CD4+ T cells playing a crucial role in the antitumor effect. This lays the groundwork for further exploration of prognostic biomarkers and predictive models for cancer patients with immunotherapy.
Authors
- Yifan Li (ORCID: https://orcid.org/0000-0001-6407-6862)
- Ruixuan Geng
- Taisheng Li (ORCID: https://orcid.org/0000-0002-7050-5675)
- Hongyu Tan (ORCID: https://orcid.org/0000-0002-8721-5068)
- Ling Chen
- Yingyi Wang (ORCID: https://orcid.org/0000-0002-1046-6731)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Thoracic Cancer
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1111/1759-7714.15493
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Medical Sciences
- Peking Union Medical College Hospital
- Peking Union Medical College
- Bijzonder Onderzoeksfonds UGent
- NIH Clinical Center