Histomorphological and Comparative Study for Cerebral Cortex Thickness and Length of Brain in Neonate of Human (Statistical and histomorphological investication)

Twenty five specimens of tissue brain at age 1-28 days after birth, were used, put in 10% formalin for fixation , then excised from the skull, for twenty hour . Samples of 0.5 cm3 thickness from frontal ,parietal ,temporal and occipital lobes are put in the fixative formalin ten percentage and then obtained for histological technique and finally stained by (H&E). The presented results were based on the analysis of a samples of 25 neonatal corps. The samples were further classified into 2 age groups, first 2 weeks of life with a sample size of 10 brain and the second was 15-28 days of age with a sample size of 15 brain. The antero-posterior cranial length was measured. In addition of the thickness of each of the 4 brain lobes were measured in triplicates and the mean of these 3 samples repeated measurements was used for comparison. The mean frontal lobe thickness ranged between 2.42 to 3.72 mm in the first group or younger age and between 3.11 to 4.28 mm in the second group or older age. The mean of frontal lobe thickness was significantly higher in older age (3.67 mm) compared to younger age (3.05mm). The mean difference in frontal lobe thickness of (0.62 mm) was evaluated as a large difference (Cohen’s d > 0.8). The histological result demonstrated that the parietal and frontal lobes were lo ated at the anterior and lateral cerebral hemisphere and the brain cortex composed by six layers and these are outer molecular and granular . external and inner pyramidal neurons external pyramidal, internal granular, internal pyramidal and polymorphic layers.