Perturbation of mammary epithelial cell apicobasal polarity by RHBDF1-facilitated nuclear translocation of PKCζ
RHBDF1-facilitated nuclear translocation of PKCζ is critically responsible for the dismantlement of epithelial cell apicobasal polarity, and thus may serve as a target in the development of therapeutic approaches against early stages of breast cancer.
Authors
- Kailiang Wu (ORCID: https://orcid.org/0000-0003-2808-3234)
- Huanyu Zhao (ORCID: https://orcid.org/0000-0003-4041-5617)
- Lu-Yuan Li (ORCID: https://orcid.org/0000-0003-1912-3556)
- Li Fu (ORCID: https://orcid.org/0000-0001-7761-5618)
- Yi-Pan Zhu
- Ying Wen (ORCID: https://orcid.org/0000-0002-1524-1048)
- Xinyu Cao (ORCID: https://orcid.org/0009-0000-9496-0974)
- Jun Sun (ORCID: https://orcid.org/0000-0001-7369-7871)
- Xinyu Ding (ORCID: https://orcid.org/0009-0006-3012-9579)
Institutions
- Second Military Medical University (CN)
- Nankai University (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- State Key Laboratory of Medicinal Chemical Biology
Publication Details
- Journal
- Biological Research
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1186/s40659-024-00566-2
- Citations
- 1
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Natural Science Foundation of China