Thymic hyperplasia after autologous hematopoietic stem cell transplantation in multiple sclerosis: a case series
Thymic hyperplasia was detected in 20% of MS patients recently treated with AHSCT. These results are consistent with previous immunological studies showing that AHSCT promotes thymus reactivation in MS patients, further supporting <i>de-novo</i> thymopoiesis as a cornerstone of immune reconstitution after AHSCT in this population.
Authors
- Edoardo Simonetti (ORCID: https://orcid.org/0000-0003-1274-5977)
- Luca Massacesi (ORCID: https://orcid.org/0000-0001-5083-372X)
- Alice Mariottini (ORCID: https://orcid.org/0000-0002-1869-7067)
- Diletta Cozzi (ORCID: https://orcid.org/0000-0001-7028-9047)
- Chiara Nozzoli
- Valentina Damato (ORCID: https://orcid.org/0000-0003-1740-4522)
- Mirella Giordano
- Riccardo Boncompagni
- Vittorio Miele (ORCID: https://orcid.org/0000-0002-2403-4999)
- Anna Maria Repice
Institutions
- Azienda Ospedaliero-Universitaria Careggi (IT)
- University of Florence (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-25
- DOI
- https://doi.org/10.3389/fimmu.2024.1478777
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.42