Static and temporal dynamic changes of intrinsic brain activity in early-onset and adult-onset schizophrenia: a fMRI study of interaction effects
Our findings unveil the static and dynamic neural activity mechanisms involved in the interaction between disorder and age in schizophrenia. Our results underscore age-related abnormalities in the neural activity of the PFC, shedding new light on the neurobiological mechanisms underlying the development of schizophrenia. This insight may offer valuable perspectives for the specific treatment of EOS in clinical settings.
Authors
- Kangkang Xue (ORCID: https://orcid.org/0000-0002-7110-8647)
- Guangyu Wu (ORCID: https://orcid.org/0000-0002-7043-2357)
- Yarui Wei (ORCID: https://orcid.org/0000-0002-4264-6374)
- Baohong Wen (ORCID: https://orcid.org/0000-0003-4566-7565)
- Xinyu Gao (ORCID: https://orcid.org/0000-0002-5175-8810)
- Jingliang Cheng (ORCID: https://orcid.org/0000-0002-6231-6591)
- Mengzhe Zhang (ORCID: https://orcid.org/0000-0003-0682-1574)
- Shaoqiang Han (ORCID: https://orcid.org/0000-0001-7331-0315)
- Jingli Chen (ORCID: https://orcid.org/0000-0002-8866-0219)
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
- High Magnetic Field Laboratory (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2024-11-25
- DOI
- https://doi.org/10.3389/fneur.2024.1445599
- Citations
- 1
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.34
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- Zhengzhou University
- Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences