Sex-specific NLRP3 activation in neutrophils promotes neutrophil recruitment and NETosis in the murine model of diffuse alveolar hemorrhage
Our results suggest a link between female sex-specific NLRP3 inflammasome activation and subsequent pulmonary NETosis in the development of pristane-induced DAH. Therefore, we identified NLRP3 inflammasome as a potential new therapeutic target in this severe complication of pro-female autoimmune disease for which specific inhibitors of NLRP3 are currently developed.
Authors
- Nicolas Schommer (ORCID: https://orcid.org/0000-0001-9568-9426)
- Denisa D. Wagner (ORCID: https://orcid.org/0000-0002-4494-413X)
- Lukas Andreas Heger (ORCID: https://orcid.org/0000-0002-9419-5675)
- William Chan (ORCID: https://orcid.org/0000-0001-9684-888X)
- Camila M. Silva (ORCID: https://orcid.org/0000-0001-8185-4435)
- Peter A. Nigrović
- Bruce M. Ewenstein (ORCID: https://orcid.org/0000-0003-3871-8619)
- Pierre Cunin (ORCID: https://orcid.org/0000-0001-8550-2306)
- Jiyoun Kim (ORCID: https://orcid.org/0000-0002-2870-6705)
- Pierre‐André Jarrot (ORCID: https://orcid.org/0000-0002-6469-9047)
- Stéphane Robert
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- Inserm (FR)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Universitäts-Herzzentrum Freiburg-Bad Krozingen (DE)
- University Medical Centre Mannheim (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-25
- DOI
- https://doi.org/10.3389/fimmu.2024.1466234
- Citations
- 8
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Lupus Research Alliance
- Philippe Foundation
- Deutsche Forschungsgemeinschaft
- Swedish Orphan Biovitrum
- National Institutes of Health