A Mendelian randomization study of alcohol use and cardiometabolic disease risk in a multi‐ancestry population from the Million Veteran Program
We replicate prior observational studies that show a U-shaped association between alcohol consumption and cardiometabolic diseases, but MR findings show no causal association between these traits. This is largely consistent with previous MR analyses in EAs and expands the literature by providing similar findings in AA and HA populations.
Authors
- Marijana Vujković (ORCID: https://orcid.org/0000-0003-4924-5714)
- Themistocles L. Assimes (ORCID: https://orcid.org/0000-0003-2349-0009)
- Amy C. Justice (ORCID: https://orcid.org/0000-0003-0139-5502)
- Benjamin Franklin Voight (ORCID: https://orcid.org/0000-0002-6205-9994)
- Christopher T. Rentsch (ORCID: https://orcid.org/0000-0002-1408-7907)
- Julie Ann Lynch (ORCID: https://orcid.org/0000-0003-0108-2127)
- Rachel L. Kember (ORCID: https://orcid.org/0000-0001-8820-2659)
- Henry R. Kranzler (ORCID: https://orcid.org/0000-0002-1018-0450)
Institutions
- VA Palo Alto Health Care System (US)
- Yale University (US)
- VA Connecticut Healthcare System (US)
- VA Salt Lake City Healthcare System (US)
- London School of Hygiene & Tropical Medicine (GB)
- Yale New Haven Health System (US)
- Translational Therapeutics (United States) (US)
- University of Pennsylvania (US)
- Stanford University (US)
Publication Details
- Journal
- Alcohol Clinical and Experimental Research
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1111/acer.15445
- Citations
- 9
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 3.82
Funders
- U.S. Department of Veterans Affairs
- VISN 4 Mental Illness Research, Education, and Clinical Center
- National Institute on Alcohol Abuse and Alcoholism
- NIH Clinical Center