Changes in retinal microvasculature and serum Gremlin-1 levels in acromegaly: A case-control study
Patients with acromegaly have decreased vascular density and lower levels of Gremlin-1 independent of glucose tolerance status. Acromegaly may cause a reduction in gremlin-1 as a compensatory mechanism due to high IGF-1 levels known as an angiogenic factor, which in turn leads to the decrease in vascular density, or gremlin-1 may already have shown a decline in response to chronic inflammation and endothelial dysfunction in acromegaly resulting in a reduction in vascular density.
Authors
- Banu Şarer Yürekli (ORCID: https://orcid.org/0000-0003-1809-2655)
- İlgın Yıldırım Şimşir (ORCID: https://orcid.org/0000-0002-6801-8499)
- Filiz Afrashı (ORCID: https://orcid.org/0000-0001-6359-1600)
- Yasemin Akçay (ORCID: https://orcid.org/0000-0002-0497-9346)
- Onur Furundaoturan (ORCID: https://orcid.org/0000-0001-6929-6645)
- Su Özgür (ORCID: https://orcid.org/0000-0002-8993-674X)
- Gökçen Ünal Kocabaş (ORCID: https://orcid.org/0000-0002-1849-3179)
- Cumali Değirmenci (ORCID: https://orcid.org/0000-0002-8268-536X)
- Cengiz Arslan (ORCID: https://orcid.org/0000-0003-4406-1131)
- Esma Pehlıvan Koroglu
- Meltem Kocamanoglu
Institutions
- Ege University (TR)
- Center for Cancer Research (US)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1016/j.pdpdt.2024.104415
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ege Üniversitesi