Hypogammaglobulinemia and severe infections in Multiple Sclerosis patients on anti-CD20 agents: A multicentre study
IgG and IgM HG occurred in a considerable proportion of patients. IgG HG increased the risk of SI, which were, nevertheless, relatively infrequent. Our results highlight the importance of monitoring immunoglobulin levels during treatment with anti-CD20 agents, to personalize treatment strategies.
Authors
- Luca Mancinelli (ORCID: https://orcid.org/0000-0003-3051-0178)
- Diana Ferraro (ORCID: https://orcid.org/0000-0003-4818-3806)
- Eleonora Baldi
- Franco Granella
- Alessio Franceschini (ORCID: https://orcid.org/0000-0003-2339-093X)
- Giulia De Napoli
- Paolo Immovilli (ORCID: https://orcid.org/0000-0001-9417-3903)
- Michele Santangelo (ORCID: https://orcid.org/0000-0003-3046-9988)
- Chiara Zini (ORCID: https://orcid.org/0000-0003-3456-4106)
- Alessandra Lugaresi (ORCID: https://orcid.org/0000-0003-2902-5589)
- Ilaria Pesci (ORCID: https://orcid.org/0009-0000-3471-0527)
- Nathaly Poma
- Ivan Panzera (ORCID: https://orcid.org/0000-0001-6114-1403)
- Krzysztof Smolik (ORCID: https://orcid.org/0009-0000-2682-6810)
- Martina Cardi (ORCID: https://orcid.org/0009-0004-2242-0652)
- Sara Montepietra
- Maria Grazia Piscaglia
- Veronica Bazzurri (ORCID: https://orcid.org/0000-0002-6071-393X)
- Matteo Foschi (ORCID: https://orcid.org/0000-0002-0321-7155)
- Alessia Fiore (ORCID: https://orcid.org/0000-0003-2885-6735)
- Francesca Maria Antonella Falzone
- Anna Maria Simone (ORCID: https://orcid.org/0000-0003-1537-3187)
- Francesca Vitetta
- Federico Camilli
- Andrea Surcinelli (ORCID: https://orcid.org/0000-0003-3779-0934)
- Clodoveo Ferri (ORCID: https://orcid.org/0000-0002-0840-5817)
- A Guareschi
Institutions
- University of Modena and Reggio Emilia (IT)
- University of Parma (IT)
- University of L'Aquila (IT)
- Azienda Unita' Sanitaria Locale Di Modena (IT)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Ospedale "Santa Maria delle Croci" di Ravenna (IT)
- Istituto Ramazzini (IT)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- Ospedale “M. Bufalini” di Cesena (IT)
- Azienda Unita' Sanitaria Locale di Parma (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Ospedale di Parma (IT)
- Guglielmo da Saliceto Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- St. Anna Hospital (DE)
- University of Bologna (IT)
Publication Details
- Journal
- Multiple Sclerosis and Related Disorders
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1016/j.msard.2024.106191
- Citations
- 14
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.95
Funders
- Bristol-Myers Squibb
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Alexion Pharmaceuticals
- Fondazione Italiana Sclerosi Multipla
- Sanofi Genzyme