Mitochondrial DNA abundance and circulating metabolomic profiling: Multivariable-adjusted and Mendelian randomization analyses in UK Biobank
Low mtDNA abundance is associated with metabolomic perturbations, particularly reflecting a pro-atherogenic metabolomic profile, which potentially could link low mtDNA abundance to higher atherosclerosis risk.
Authors
- Raymond Noordam (ORCID: https://orcid.org/0000-0001-7801-809X)
- Diana van Heemst (ORCID: https://orcid.org/0000-0001-8526-7748)
- Jiao Luo (ORCID: https://orcid.org/0000-0001-8511-8945)
- Sara Hägg (ORCID: https://orcid.org/0000-0002-2452-1500)
- Felix Graßmann (ORCID: https://orcid.org/0000-0003-1390-7528)
- Saskia le Cessie (ORCID: https://orcid.org/0000-0003-2154-4923)
- Ko Willems van Dijk (ORCID: https://orcid.org/0000-0002-2172-7394)
Institutions
- Leiden University Medical Center (NL)
- Science for Life Laboratory (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Mitochondrion
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1016/j.mito.2024.101991
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Velux Stiftung
- Karolinska Institutet
- Vetenskapsrådet