HBx Facilitates Drug Resistance in Hepatocellular Carcinoma via CD133-regulated Self-renewal of Liver Cancer Stem Cells
Our data suggest that HBV replication enhances the stemness and drug resistance of HCC, providing a strong theoretical foundation for the development of targeted and efficient treatments for HBV-infected HCCs.
Authors
- Xiangshu Jin (ORCID: https://orcid.org/0000-0002-6551-8850)
- Xinyuan Lai
- Xing Tian (ORCID: https://orcid.org/0000-0003-1629-6304)
- Huijun Dong (ORCID: https://orcid.org/0000-0002-6899-879X)
- Kuanhui Xiang (ORCID: https://orcid.org/0000-0001-5022-5863)
- Hui Zhuang (ORCID: https://orcid.org/0009-0002-0081-4322)
- Tong Li (ORCID: https://orcid.org/0000-0002-2972-1616)
- Guomin Ou (ORCID: https://orcid.org/0000-0001-8902-9157)
- Juan Wang (ORCID: https://orcid.org/0000-0002-2531-2188)
- Lei Wang (ORCID: https://orcid.org/0000-0003-0734-7026)
Institutions
- Qingdao University (CN)
- Shenyang Medical College (CN)
- Peking University (CN)
- Chinese PLA General Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Journal of Clinical and Translational Hepatology
- Published
- 2024-11-25
- DOI
- https://doi.org/10.14218/jcth.2024.00259
- Citations
- 5
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- National Natural Science Foundation of China
- Peking University
- Peking University Health Science Center