Osteopontin neutralization increases vitamin D receptors on NKT cells and ameliorates liver fibrosis by promoting their activity
VDR expressions affect trNKT cells activity and could modulate progressions of liver fibrosis. Using an OPN-neutralizing antibody exhibited an antifibrotic effect by alleviating the liver injury profile through NKT cells. It is also suggested as an immunomodulatory target of liver fibrosis.
Authors
- Johnny Amer (ORCID: https://orcid.org/0000-0001-5828-6783)
- Ahmad Salhab (ORCID: https://orcid.org/0000-0003-3556-1054)
- Enas Hussini
- Rasha Shweiki
- Iman Zahran
- Mohammad Far
Institutions
- An-Najah National University (PS)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-25
- DOI
- https://doi.org/10.3389/fphar.2024.1484278
- Citations
- 2
- Primary Topic
- Digestive system and related health
- Type
- article
- Field-Weighted Citation Impact
- 1.10