Regulation of cochlear hair cell function by intracellular calcium stores
We concluded that the most likely physiological role of IP<sub>3</sub>-gated Ca<sup>2+</sup> release at the apex of the cell is the regulation of hair bundle stiffness. In contrast, Ca<sup>2+</sup>-induced Ca<sup>2+</sup> release at the base of OHCs seems to regulate axial stiffness of the cells and its hyperpolarization in response to efferent stimuli, without direct effects on the OHC prestin-based membrane motors.
Authors
- Ghanshyam P. Sinha (ORCID: https://orcid.org/0000-0003-3190-2878)
- Gregory I. Frolenkov (ORCID: https://orcid.org/0000-0002-9810-5024)
Institutions
- University of Kentucky (US)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2024-11-25
- DOI
- https://doi.org/10.3389/fncel.2024.1484998
- Citations
- 2
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders