The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons
These results indicate that the reduction of catB function negatively impacts lysosomal pathways associated with PD pathogenesis, while conversely catB activation could promote the clearance of pathogenic alpha-synuclein.
Authors
- Konstantin A. Senkevich (ORCID: https://orcid.org/0000-0003-3407-5716)
- Austen J. Milnerwood (ORCID: https://orcid.org/0000-0002-0056-1778)
- Farnaz Asayesh
- Stanley Fahn
- Jace Jones-Tabah (ORCID: https://orcid.org/0000-0002-7932-5080)
- Thomas M. Durcan (ORCID: https://orcid.org/0000-0003-3942-1956)
- Esther del Cid‐Pellitero (ORCID: https://orcid.org/0000-0001-8658-944X)
- Carol X.‐Q. Chen (ORCID: https://orcid.org/0000-0001-6167-8083)
- Cheryl Waters (ORCID: https://orcid.org/0000-0002-1908-8773)
- Edward A. Fon (ORCID: https://orcid.org/0000-0002-5520-6239)
- Jennifer A. Ruskey (ORCID: https://orcid.org/0000-0002-6392-5014)
- Oury Monchi (ORCID: https://orcid.org/0000-0003-2148-5409)
- Sharon Hassin‐Baer (ORCID: https://orcid.org/0000-0001-7657-0171)
- Roy N. Alcalay (ORCID: https://orcid.org/0000-0002-5717-4875)
- Daria Nikanorova
- Irina Miliukhina (ORCID: https://orcid.org/0000-0002-6433-542X)
- Wen Luo (ORCID: https://orcid.org/0000-0003-1785-9615)
- Dan Spiegelman (ORCID: https://orcid.org/0000-0003-4971-8868)
- Lior Greenbaum (ORCID: https://orcid.org/0000-0001-6176-0941)
- Narges Abdian (ORCID: https://orcid.org/0000-0003-0858-1391)
- Taylor Goldsmith (ORCID: https://orcid.org/0009-0002-4247-9884)
- Nicolas Dupré (ORCID: https://orcid.org/0000-0001-7270-6115)
- Thomas Goiran (ORCID: https://orcid.org/0000-0001-5838-8798)
- Yves A Dauvilliers (ORCID: https://orcid.org/0000-0003-0683-6506)
- Ziv Gan‐Or (ORCID: https://orcid.org/0000-0003-0332-234X)
- Yuting Cousineau
- Nathan Karpilovsky
- Isabella Pietrantonio (ORCID: https://orcid.org/0009-0001-2657-3072)
- Ghislaine Deyab
- Jamil Ahmad (ORCID: https://orcid.org/0000-0002-0320-4020)
- Alla Timofeeva (ORCID: https://orcid.org/0000-0003-1661-7753)
- Zhipeng You (ORCID: https://orcid.org/0000-0001-8779-5712)
- Anton Emelyanov (ORCID: https://orcid.org/0000-0002-3249-7889)
- Sofya Pchelina
- Kathy He
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Tel Aviv University (IL)
- Université de Montpellier (FR)
- Columbia University Irving Medical Center (US)
- First Pavlov State Medical University of St. Petersburg (RU)
- Tel Aviv Sourasky Medical Center (IL)
- Sheba Medical Center (IL)
- Institute of the Human Brain (RU)
- Hôpital Gui de Chauliac (FR)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Bioinformatics Institute (RU)
- Université Laval (CA)
- McGill University (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1186/s13024-024-00779-9
- Citations
- 26
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 9.60
Funders
- Brookdale Foundation
- McGill University
- Parkinson's Foundation
- Consortium canadien en neurodégénérescence associée au vieillissement
- Parkinson Canada
- Canada First Research Excellence Fund
- National Institutes of Health
- Canadian Institutes of Health Research