Clerodendranthus spicatus [Orthosiphon aristatus (Blume) Miq.] maintains uric acid homeostasis via regulating gut microbiota and restrains renal inflammation in hyperuricemic nephropathy
Our results demonstrated that <i>C. spicatus</i> could reduce uric acid levels, anti-inflammatory effects, and improve HN by regulating the gut microbiota. This provides a novel scientific basis for the clinical application of <i>C. spicatus</i>.
Authors
- Mei‐Fang Cheng (ORCID: https://orcid.org/0000-0002-9359-0606)
- Yuzheng Wu (ORCID: https://orcid.org/0000-0002-7817-329X)
- Yang Wang (ORCID: https://orcid.org/0000-0002-4514-2534)
- Dan Wang (ORCID: https://orcid.org/0000-0002-8264-1586)
- Qian Chen (ORCID: https://orcid.org/0000-0002-7916-1370)
- Ge Li (ORCID: https://orcid.org/0000-0001-9030-884X)
- Tao Wang (ORCID: https://orcid.org/0000-0003-1225-0173)
- Kaiwen Li (ORCID: https://orcid.org/0000-0002-4988-2687)
- Siya Yan
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-25
- DOI
- https://doi.org/10.3389/fphar.2024.1485861
- Citations
- 3
- Primary Topic
- Bioactive Compounds in Plants
- Type
- article
- Field-Weighted Citation Impact
- 1.80
Funders
- National Natural Science Foundation of China