Transglutaminase 2 regulates endothelial cell calcification via IL-6-mediated autophagy
ECs are not only critical for atherogenesis but also believed to be a source of osteoprogenitor cells that initiate intimal calcification. Previous research has shown that TG2 plays an important role in the development of VC, but the mechanism by which it exerts this effect is not yet fully understood. Our results demonstrated that TG2 forms complexes with NF-κB components inhibition of autophagy promoted endothelial cell calcification through EndMT. Therefore, our research investigated the molecular mechanism of EC calcification, which can provide new insights into the pathogenesis of atherosclerosis.
Authors
- Peng Lv (ORCID: https://orcid.org/0000-0001-9759-608X)
- Bin Zhang
- Qian Zheng (ORCID: https://orcid.org/0000-0001-8400-6298)
- Bo Liu (ORCID: https://orcid.org/0009-0008-0832-4532)
- C. Y. Li
- Ying Cui (ORCID: https://orcid.org/0000-0002-3697-5155)
- Jingye Li (ORCID: https://orcid.org/0000-0003-2351-2546)
- Xinyue Liu (ORCID: https://orcid.org/0000-0002-2145-1674)
- Zhiyuan Cai (ORCID: https://orcid.org/0000-0002-7096-6658)
- Dongwei Yang
- Yan Wang (ORCID: https://orcid.org/0000-0001-6111-5379)
Institutions
- Second Affiliated Hospital of Zhengzhou University (CN)
- Zhengzhou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-25
- DOI
- https://doi.org/10.3389/fphar.2024.1393534
- Citations
- 3
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- Henan Provincial Science and Technology Research Project