Analysis of Germline and Somatic Mutation in Patients With Developmental Odontogenic Cysts Using Targeted Gene Panel
We found one patient with GS from those diagnosed with sporadic OKC. Our findings suggest that PTCH1 mutations are associated with postoperative recurrence of OKC, implying that hedgehog-related gene variations may contribute to jaw cyst development and improve the prognosis of OKC.
Authors
- Shoko Onodera (ORCID: https://orcid.org/0000-0003-0673-3400)
- Masayuki Takano (ORCID: https://orcid.org/0000-0003-3971-5276)
- Kenichi Matsuzaka (ORCID: https://orcid.org/0000-0002-7613-7105)
- Yuriko Nakamura (ORCID: https://orcid.org/0000-0003-4226-0655)
- Akira Katakura (ORCID: https://orcid.org/0000-0002-9761-1267)
- Yoshihiko Akashi (ORCID: https://orcid.org/0000-0003-2262-5610)
- Toshifumi Azuma (ORCID: https://orcid.org/0000-0002-0746-8138)
- Takeshi Nomura
- Itsuki Hideshima
Institutions
- Tokyo Dental College (JP)
- Tokyo Dental College Ichikawa General Hospital (JP)
Publication Details
- Journal
- Journal of Oral Pathology and Medicine
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1111/jop.13586
- Citations
- 1
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Japan Society for the Promotion of Science