S1P/S1PRs‐TRPV4 axis is a novel therapeutic target for persistent pain and itch in chronic dermatitis
Our results indicate that, in CD, increased S1P induces chronic pain and itch partly through TRPV4. Inhibition of S1P synthesis or the S1P/S1P receptor-TRPV4 pathway are promising treatment strategies for CD-associated pain and itch.
Authors
- Xue Li (ORCID: https://orcid.org/0000-0001-6880-2577)
- Zongxiang Tang (ORCID: https://orcid.org/0000-0003-1631-0970)
- QI Ming-xin
- Fang Wang (ORCID: https://orcid.org/0000-0002-5971-2622)
- Guang Yu (ORCID: https://orcid.org/0000-0001-7918-0160)
- Jiahui Ren
- Yan Yang (ORCID: https://orcid.org/0000-0002-1860-2857)
- Weimeng Feng (ORCID: https://orcid.org/0000-0002-6472-0416)
- Chan Zhu (ORCID: https://orcid.org/0000-0001-9760-2531)
- Yuxiang Ma (ORCID: https://orcid.org/0000-0003-1173-8441)
- Changming Wang (ORCID: https://orcid.org/0000-0002-8632-7666)
- Pei Liu (ORCID: https://orcid.org/0000-0002-8664-9892)
- Yin Wang
- Yuan Zhou (ORCID: https://orcid.org/0000-0002-4165-0718)
- Xinyu Zhang (ORCID: https://orcid.org/0009-0000-2893-3986)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- China Pharmaceutical University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1111/bph.17393
- Citations
- 4
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.14
Funders
- National Natural Science Foundation of China
- Basic Research Program of Jiangsu Province