Combined metabolic engineering and lipid droplets degradation to increase vitamin A production in Saccharomyces cerevisiae
Overall, our results highlighted the significance of sequential degrading LDs on vitamin A overproduction in recombinant yeast, and verified that combining metabolic and LDs engineering is an efficient strategy to improve vitamin A production. This integrated strategy can be applied to the overproduction of other hydrophobic compounds with similar characteristics.
Authors
- J.-B. Lin
- Chang‐Qing Duan (ORCID: https://orcid.org/0000-0002-5218-8266)
- Xiao Bu
- Yibin Lan (ORCID: https://orcid.org/0000-0002-2474-2522)
- Guoliang Yan (ORCID: https://orcid.org/0000-0001-9936-4776)
Institutions
- Jiangsu Agri-animal Husbandry Vocational College (CN)
- Ministry of Agriculture and Rural Affairs (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2024-11-25
- DOI
- https://doi.org/10.1186/s12934-024-02596-7
- Citations
- 9
- Primary Topic
- Microbial Metabolic Engineering and Bioproduction
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- National Key Research and Development Program of China