Dexmedetomidine inhibits ferroptosis and attenuates sepsis-induced acute kidney injury via activating the Nrf2/SLC7A11/FSP1/CoQ10 pathway
DEX mitigated ferroptosis and attenuated S-AKI by activating the Nrf2/SLC7A11/FSP1/CoQ10 pathway. Abbreviation: CLP: Cecal ligation puncture; LPS: Lipopolysaccharide; Nrf2: Nuclear factor-erythroid- 2-related factor 2; SLC7A11: Solute carrier family 7 member 11; FSP1: Ferroptosis suppressor protein 1; CoQ10: Coenzyme Q10; BUN: Blood urea nitrogen; Cr: Serum creatinine; ROS: Reactive oxygen species; MDA: Malondialdehyde; 4-HNE: 4-hydroxynonenal; GSH: Hlutathione; GPX4: Glutathione peroxidase 4.
Authors
- Yunan Lin (ORCID: https://orcid.org/0000-0001-9440-6164)
- Yunpeng Luo (ORCID: https://orcid.org/0000-0002-7838-5241)
- Jian Lai (ORCID: https://orcid.org/0000-0001-5851-9698)
- Jiao Huang (ORCID: https://orcid.org/0000-0002-6275-0451)
- Jiemei Ji
- Yang Zhao (ORCID: https://orcid.org/0000-0001-9163-5498)
- Jia Li (ORCID: https://orcid.org/0000-0002-5965-3829)
- Yuanyuan Chen (ORCID: https://orcid.org/0009-0007-8048-5763)
- Xi Luo (ORCID: https://orcid.org/0000-0002-2796-1878)
- Jingchen Liu (ORCID: https://orcid.org/0000-0002-6730-5701)
- Ziru Liu
Institutions
- Guangxi Medical University (CN)
- Zunyi Medical University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Yueyang Hospital (CN)
- Guizhou Provincial People's Hospital (CN)
Publication Details
- Journal
- Redox Report
- Published
- 2024-11-24
- DOI
- https://doi.org/10.1080/13510002.2024.2430929
- Citations
- 22
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 9.22
Funders
- National Natural Science Foundation of China